Amyotrophic Lateral Sclerosis by Hiroshi Mitsumoto MD

By Hiroshi Mitsumoto MD

Amyotrophic Lateral Sclerosis provides the main accomplished, clinically-focused details on ALS (Lou Gehrig's ailment) in print. the 3 authors, well known for his or her paintings during this zone, offer cohesive and balanced assurance of this syndrome, together with the background, medical positive factors, pathology and pathogenesis, remedy and administration of ALS. To facilitate knowing, each one bankruptcy is superior through finished tables and figures, in addition to targeted bankruptcy summaries.

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Doc Med Geog Trop 5:366-370, 1953. 64. Tyler, HR and Shefner, J: Amyotrophic lateral sclerosis. In Vinken, PJ, Bruyn, GW, and Klawans, HL, History, Terminology, and Classification of ALS (eds): Diseases of the Motor System, vol 59. Elsevier, New York, 1975, pp 169-216. 65. Uebayashi, Y: Epidemiological investigation of motor neuron disease in the Kii Peninsula, Japan and on Guam: The significance of long survival cases. Wakayama Med Rep 23:13-27, 1980. 66. World Federation of Neurology Research Group on Neuromuscular Diseases Subcommittee on Motor Neuron Disease: El Escorial World Federation 17 of Neurology criteria for the diagnosis of amyotrophic lateral sclerosis.

A subgroup characterized by posterior and spinocerebellar tract involvement and hyaline inclusions in the anterior horn cells, Arch Neurol 16:232-243, 1967. 34. Hirano, A, Malamud, N, and Kurland, L: Parkinsonism-dementia complex, an endemic disease on the Island of Guam. II Pathological features. Brain 84:662-679,1961. 35. Horton, WA, Eldridge, R, and Brody, JA: Familial motor neuron disease. Neurology 26:460-465, 1976. 36. Hudson, AJ: Amyotrophic lateral sclerosis: Clinical evidence for differences in pathogenesis and etiology.

In most cases, however, the symptoms of upper and lower motor neuron lesions are mixed, except in the lower limbs, where the latter are frequently absent until the terminal stages. Greenfield 29 prefers the term ALS to motor neuron disease on the grounds that the pathological changes in the spinal cord are not limited to the motor neurons and many American authors use this term as an inclusive one, embracing all varieties of the disease. Motor neuron disease, however, is a better inclusive term.

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